ea0016p56 | Adrenal | ECE2008
Kanczkowski Waldemar
, Morawietz Henning
, Zacharowski Kai
, Ziegler Christian G
, Ehrhart-Bornstein Monika
, Bornstein Stephan R
Sepsis and septic shock remain a major health concern worldwide, and an intact adrenal cortex glucocorticoid (GC) stress response, is critical for organism to survive. Recently, we and others have shown that adrenal gland expresses members of toll-like receptors (TLRs) family which are known to sense pathogens and induce inflammatory response. Data performed on TLRs deficient mice clearly demonstrate a critical involvement of these receptors in immune-neuroendocrine bidirectio...